Suppressors of Cytokine Signaling (SOCS) Proteins Induce Insulin-Resistance in the Retina and Promote Survival of Retinal Cells

نویسندگان

  • Xuebin Liu
  • Marie G. Mameza
  • Yunsang Lee
  • Chikezie I. Eseonu
  • Cheng-Rong Yu
  • Jennifer J. Kang Derwent
  • Charles E. Egwuagu
چکیده

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Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells.

OBJECTIVE Suppressors of cytokine signaling (SOCS) are implicated in the etiology of diabetes, obesity, and metabolic syndrome. Here, we show that some SOCS members are induced, while others are constitutively expressed, in retina and examine whether persistent elevation of SOCS levels in retina by chronic inflammation or cellular stress predisposes to developing insulin resistance in retina, a...

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BACKGROUND Suppressors of cytokine signalling (SOCS) protein family are key regulators of cellular responses to cytokines and play an important role in the nervous system. The SOCS6 protein, a less extensively studied SOCS family member, has been shown to induce insulin resistance in the retina and promote survival of the retinal neurons. But no reports are available about the role of SOCS6 in ...

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تاریخ انتشار 2008